Clinical Characteristics of Double SeroPositive Myasthenia Gravis

Objective This study aims to delineate the clinical phenotype of DSP-MG and assess histopathological correlation with thymoma. Background Double SeroPositive Myasthenia Gravis (DSP-MG), a rare autoimmune disease that affects neuromuscular transmission, is characterized by antibodies against both AChR MuSK receptors. second be conducted in world which attempts define patients. Design/Methods retrospective case series at tertiary care hospital South India between February 2018 October 2021. All patients who were diagnosed based on typical presentation positive titres Anti- Anti-MuSK included study. Results consisted 13 (7 Females, Mean age- 60.77 +/-14.24). The was generalized 9 patients, bulbar 3 ocular 1 patient. Severity assessed using Modified Osserman System wherein 5 Grade 4, 4 grade 3, 2 while patient 1. muscle groups affected first limbs (n = 6), 5), 3) respiratory 1). MDCT done 11 showed thymoma five thymic hyperplasia Four underwent thymectomy whose histopathology Type A, B2 2) AB thymomas. had associated thyroid dysfunction found have developed MG post stroke. improved Anticholinesterases, administered immunosuppressants, given IVIg single plasmapheresis. Conclusions Our shows DSP more similar AChR-MG, rather than MuSK-MG has been previously defined literature.